IgA: They are found in mucosal areas such as the urogenital tract, gut, and respiratory tract. They are also found in tears, saliva, and breast milk. They attack microbes and prevent colonization by pathogens before they reach the blood stream.
IgD: They are found on inactivated B-cells. They also activate basophils and mast cells which produce antimicrobial factors.
IgG: They are the most common and make up about 75% of all antibodies. They are the only one to be able to cross the placenta to the fetus. They are the most versatile.
IgE: They bind to allergens which causes the release of histamine from mast cells and basophils. They are mainly involved in allergies.
IgM: They are first to eliminate the pathogen before IgG arrives. They are expressed on the surface of B-cells.
Major Organ:
Thymus: It is the site of T-cell maturation. It is located in the upper area of the chest behind the sternum and between the lungs. It is pinkish-grey.
There are other organs that you will learn about in the next couple of lessons.
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