Ok. We will start with the Inflammatory Process. First, a pathogen will be recognized by a macrophage. The macrophage will release chemical signals to activate other cells. The mast cells will release histamine. Histamine is a potent inflammatory agent.
The injured tissue cells will release chemicals also. These chemicals will cause capillary dilation or capillary widening. This will result in hyperemia or increased blood flow. The chemicals will increase vascular permeability. This means that proteins and cells can easily diffuse across blood vessel membranes.
The increased vascular permeability will allow edema to occur. Edema is the surge of fluid containing clotting factors and antibodies into tissue spaces of the injured tissue. Edema will provide nutrients to the tissue cells, antibodies for defense, and clotting proteins. The clotting proteins help stop the spread of bacteria with fibrin.
Now we get to PHAGOCYTE (eating cell) MOBILIZATION. Phagocyte mobilization contains 4 main parts.
1. Leukocytosis: Neutrophils are released from the bone marrow.
2. Margination: Neutrophils cling to the capillary wall.
3. Diapedesis: Neutrophils squeeze through the capillary wall near the tissue area.
4. Chemotaxis: Neutrophils are attracted to the injured tissue by inflammatory chemicals.
This diagram is a visual representation of Phagocyte Mobilization.
This diagram summarizes tissue injury.
I hope this post helped!
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